Explore Albrem’s Solution Areas
Custom Protein Expression & Translational Development
For teams that need rapid protein production, comparative expression strategies, candidate screening, and early translational decision support before larger downstream investment.
Best fit when you need to:
- Produce & compare candidates quickly
- Evaluate Cell-Free, E. coli, and CHO options
- Generate functional material and analytical data
- Support candidate selection before IND-enabling work
Primary Deliverables:
- Purified protein material
- Comparative expression data
- Analytical characterization
- Candidate readiness recommendations
Difficult-to-Express Proteins
For proteins that fail in conventional systems because of toxicity, aggregation, folding complexity, or scale-up instability.
Best fit when you need to:
- Rescue stalled expression programs
- Address toxicity-related host failure
- Improve folding or solubility
- Determine whether a difficult target is still viable
Primary deliverables may include:
- Rescue feasibility data
- Soluble protein when successful
- Solubility and yield observations
- Downstream production recommendations
Protein Engineering & Optimization
For teams with promising protein candidates that need improved stability, activity, affinity, solubility, expression, or developability before downstream studies.
Best fit when you need to:
- Improve candidate performance
- Design focused variant libraries
- Reduce aggregation or instability
- Generate functional and developability data before larger investment
Primary deliverables may include:
- Ranked variant designs
- Focused libraries
- Optimized constructs
- Functional/stability data
- Candidate advancement recommendations.
Custom Formulation & Assay Support
For teams that need assay-ready proteins or custom reagents supported by validation and stability data rather than standard purified material alone.
Best fit when you need to:
- Prepare proteins for diagnostic or analytical use
- Support assay development with validated reagents
- Control labeling or modification strategy
- Reduce risk from poorly characterized reagent inputs
Primary deliverables may include:
- Assay-ready reagents
- Functional validation summaries
- Purity and identity confirmation
- Stability profiling and controlled modification support
What These Solutions Have in Common
Albrem’s solutions are designed to help teams move from sequence, concept, or problematic candidate toward a clearer development decision. Across these solution areas, our work is centered on:
Rapid experimental learning cycles
Protein production and optimization for discovery and translational use
Analytical characterization to support decision-making
Generation of functional, better-understood material
Handoff-ready data packages for next-stage development planning
Who These Solutions Are For
Albrem’s solutions are designed for biotechnology teams that need data and material to guide development decisions, including situations such as:
A target has been identified, but candidate performance still needs confirmation
Multiple variants must be screened without a long linear workflow
A protein is unstable, poorly soluble, or difficult to express
A candidate needs improvement before more substantial downstream investment
An assay or analytical workflow requires functional, validated reagent material
Investors, partners, or internal stakeholders need stronger supporting data
Why Teams Use Albrem
Faster learning, not just material output
Albrem is structured to support rapid iteration and earlier technical clarity, rather than acting only as a bulk production provider.
Multi-path problem solving
Across the solutions portfolio, Albrem can address expression, optimization, rescue, and assay-readiness challenges using different but connected workflows.
Decision-ready data packages
The emphasis is on generating material plus supporting analytical and functional information that can be used internally or in partner, investor, or downstream handoff contexts.
Fee-for-service model
Albrem’s service model is positioned around client programs and client ownership, with a focus on practical progress through discovery and translational stages.
How Albrem Supports Development Decisions
1
Define the objective
We begin with the target, sequence or construct, intended use, and the most important technical question—expression, optimization, rescue, or assay-readiness.
2
Select the right workflow
Depending on the program, Albrem applies the relevant combination of expression platform selection, engineering strategy, rescue workflow, purification, modification, formulation, and analytics.
3
Generate decision-grade outputs
The goal is not just to produce material, but to generate data that helps determine what to advance, what to rework, and what to stop.
Core Platform Strengths Across the Solutions Portfolio
- Develop ECL (electrochemiluminescence) or FRET screening assays for binding evets selection.
- Perform orthogonal analytical assays (e.g., SPR, MST, ITC) to confirm binding characteristics.
- Provide supplementary automated analytical workflows for throughput enhancement and characterization.
- Support protein incorporation of non-canonical amino acids and tagging.
- Optimize production output via strain testing, impurity profiling and metabolomics analysis.
- Express selected proteins in mammalian systems, transient or stable.
- Conduct comparative bioactivity assays between cell-based and cell-free derived proteins.
- Develop workflows to produce and enhance selected variants.
- Analyze variants for structural and functional properties via analytical testing (CE, SEC, RP-HPLC) and MS.
- Perform stability profiling and stress testing to select optimal evolved variants.
- Characterize protein integrity, aggregation, or post-translational modifications.
- Provide analytical batch testing (CE, SEC, RP-HPLC) for identity, purity, and potency.
- Conduct endotoxin testing and residual host cell protein (HCP) or DNA analysis.
- Evaluate protein integrity and degradation under storage or process conditions.
- Perform cell-free protein synthesis at scale-up conditions.
- Perform preliminary stability studies (accelerated and long-term) under ICH guidelines.
- Test for aggregation, oxidation, and fragmentation via RP or SEC-HPLC and LC-MS/MS.
- Conduct formulation solubility and compatibility studies for downstream bioanalytical testing.
- Offer pre-formulation screening for pH, buffer, excipients, and surfactant compatibility.
- Conduct forced degradation studies to assess formulation robustness.
- Evaluate thermal, photolytic, and mechanical stress on formulated proteins.
- Offer lyophilization and DOE-based formulation optimization through industry partners.
- Conduct endotoxin quantification (e.g., LAL or recombinant factor C assays).
- Test for residual impurities (e.g., detergents, nucleic acids, host cell proteins).
- Provide GLP-compliant characterization for tox submission batches.
- Develop and validate LC-MS/MS or HRMS-based screening for binding interactions with industry partner.
- Execute comprehensive CoT testing including: - CE-SDS and icIEF for charge and size variants / - RP-HPLC, SEC, SPR, ELISA, as well as MS, ECL and Q-NMR where applicable (through our industry partners)
- Provide GLP and non-GLP CoT packages depending on study stage.
- Supply custom certificate formats to match regulatory or partner-specific requirements.
Our expertise can help to advance your projects
We can also provide services for support of process development, including expertise in cell-free protein synthesis, mammalian cell-based expression, and analytical characterization.